What is Lennox Gastaut Syndrome (LGS)?
Lennox-Gastaut Syndrome is a rare and severe form of childhood-onset epilepsy that is characterized by frequent, uncontrolled seizures, moderate to severe cognitive impairment, and a slow-spike wave EEG pattern.
How is LGS Diagnosed?
Criteria are mentioned above
What causes LGS?
There are a variety of known causes of LGS. They include a history of infantile spasms, brain malformations, infections such as meningitis or encephalitis, genetic mutations, and brain injury associated with birth. In 30% of cases, the cause is not yet known.
What Are The Most Common Characteristics?
Frequent, uncontrolled seizures, developmental delay, regression, behavioral co-morbidities. The peak onset of diagnosis is between the ages of 3-5.
Is LGS genetic?
Progress in whole exome sequencing over the past decade has revealed that some individuals with LGS have de novo genetic mutations in a variety of genes.
How is LGS Treated?
There are six FDA approved medications for LGS. Additionally, there are dozens of other anti-epileptic medications used in treating LGS. Dietary therapy, the vagus nerve stimulator, and surgery are also used.
Who should I consult if I suspect LGS?
An epileptologist, which is a neurologist who has extensive training in epilepsy.
Lennox Gastaut Syndrome: Any helpful learning strategies?
What are the first steps to take? First step is to see an epileptologist at a level four epilepsy center. Diagnostic testing such as EEGs and MRIs are imperative. Genetic testing is also very important; knowing the gene mutation may help alter treatment.
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For more information contact: The LGS Foundation [2]
The LGS Foundation [2] is a nonprofit organization dedicated to improving the lives of individuals living with Lennox-Gastaut Syndrome, a rare and severe form of childhood-onset epilepsy through research, family support programs, and education.
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